Regressing is running a series on the biggest plays of the week. I created a tool for them them lists the biggest plays in terms of Win Probability Added (WPA).
Reading the comments, people seem to take delight in the negative plays for whatever reason. Cutler's interceptions appear to invite a lot of anti-fans. There's also loyal fans who like to pile on the misfortunes of their own team out of frustration. I can see that this week with E.J. Manuel's bad day yesterday.
But keep in mind a "negative" play is all in the perspective. A bad play to an offense is a great play to a defense. Statistically, there is no good and bad. Manuel's interception to Watt was both a poor by play by a quarterback and an alert and athletic play by a defensive lineman.
If and when Regressing gets tired of posting these, I'll make the tool public so you can look up the most agonizing moments in your hometown team's season anytime you want.